In Dupuytren disease, which injectable therapy is used for contractures?

• A. Observation
• B. Surgical fasciectomy
• C. Radiation therapy
• D. Collagenase injection

Answer: (D)

In Dupuytren disease, the problem is a thickened cord of palmar fascia that causes finger contractures. The injectable option that directly targets this cord is collagenase injection. It uses an enzyme to break down the collagen in the cord, weakening it so the finger can be straightened with a controlled manual stretch a day or two after injection. This makes it a minimally invasive alternative to surgery for suitable palpable cords and contractures.

Observation won’t help if a contracture is already limiting function. Surgical fasciectomy removes the diseased tissue but is invasive and requires more recovery. Radiation therapy can slow progression in some early cases but doesn’t correct established contractures. So collagenase injection stands out as the injectable therapy designed to address the cord itself and reduce contracture.